Joseph and the Amazing Technicolor Neural Tube
Joseph and the Amazing Technicolor Neural Tube
Juana De La O, Chidera Okeke, Adam C. Martin
During development, tissues are pushed, pulled, and folded into complex shapes. The brain begins as a flat sheet of cells, called the neural plate, that folds into a neural tube. The neural plate has a network of force producing filaments on its surface that helps fold it into the neural tube. To understand how the network promotes neural tube folding, we’ve created the first high-resolution images of the filaments across the surface of the folding neural tube. The pattern of filaments we observe have allowed us to build a model of the mechanics necessary to fold the neural tube in mammals.