Sweet details can reveal darker secrets. These circular immune compartments come from human tissue, with healthy samples on the left and follicular lymphoma on the right. While the cells appear similar, their pattern of surface sugars (green) changes dramatically in cancer.  With a new imaging approach, the researchers can uncover abnormal sugar patterns found only in tumors. By studying this glycosylation, they reveal hidden signals that help cancer grow, and identify new ways to diagnose and treat disease.