Dancing With The Cells: Spotlight On Plasma Membrane

Dancing With The Cells: Spotlight On Plasma Membrane

Collections: Image Award Winners, Cancer Discovery Science

2023 Award Winner

Teemu P. Miettinen and Scott R. Manalis

Koch Institute at MIT

The Manalis Lab studies the mechanical and biophysical changes that occur during cell division. In this experiment, researchers track the organization of the plasma membrane (red/yellow) as a live human adenocarcinoma cell divides in two.

A lingering plasma bridge (center) contains remnants of DNA (blue) that failed to separate between the daughter cells. Such segregation errors can result in mutations that can initiate and drive cancer.

Understanding how plasma membrane movement is regulated as normal and cancer cells divide could help explain how mutations arise and how to prevent them.

orange material stretches between and around two dividing cells with bright nuclei


Teemu Miettinen presents on his image.

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