Brains and Brawn: Building a Neuronal Network

Brains and Brawn: Building a Neuronal Network

Collections: Image Award Winners

2020 Award Winner

Ellen DeGennaro, Christopher A. Walsh

Boston Children's Hospital, Harvard-MIT Division of Health Sciences and Technology

Like children in gym class, young brain cells pull themselves up a rope-like fiber to form a neuronal network. Near the hollow, fluid-filled ventricle (lower left) teardrop-shaped neurons are undifferentiated, having recently split off from their mother cells.

As they migrate outward toward the cortical plate, leapfrogging over one another, they mature and anchor near the pial surface (blue/green) to assume their final positions in the developing brain.

Walsh Lab researchers created this architectural map to better understand how a cell’s position and lineage influence its fate.

strands of neurons looking like spokes on a wheel

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