Huntingtin Protein Expression in Fly Neurons

Huntingtin Protein Expression in Fly Neurons

Submitted by J. Troy Littleton of the Picower Institute for Learning and Memory

Picower Institute for Learning and Memory, MIT Department of Brain and Cognitive Sciences

J. Troy Littleton
Picower Institute for Learning and Memory
Confocal Micrograph

"This image shows Drosophila cultured neurons expressing membrane-tethered GFP (green) and the human Huntingtin protein (red). 

Joost Schulte, a post-doc in my lab, was looking for drugs that reduce neurotoxicity in the neurodegenerative disorder, Huntington’s Disease. An expansion of a polyglutamine stretch within the Huntingtin protein causes it to misfold and damage neurons."

 

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