Here we see electron microscopy revealing the intricate damage to brain cells caused by Huntington’s disease, providing crucial insight into how emerging gene therapies may reverse these destructive changes. 

This image is integral to our efforts to develop effective treatments for Huntington's disease (HD) and related repeat expansion disorders. It illustrates the severe structural disruptions caused by HD at the neuronal level, such as swelling and mitochondrial dysfunction, which contribute to the degenerative effects observed in the disease. By visualizing these structural abnormalities with a high degree of precision, we can directly assess the impact of HD on cellular health. 

Researchers  are working on gene therapy approaches that could restore or protect these cellular components, ultimately aiming to halt or reverse the progression of HD.