This image represents 2-dimensional classes of Met18 protein particles. As in, these are averaged images of how Met18 looks when frozen! Each panel represents a different orientation of the protein complex, showing how the complex looks, which can help us understand its function better.

I took these images to understand the structure of Met18 on its own to better understand its function and regulation in the Cytosolic Iron-sulfur cluster Assembly (CIA) pathway. Along with proteins Cia1 and Cia2, Met18 forms the CIA targeting complex (CTC), which transfers a mature iron-sulfur cluster to cytosolic and nuclear client proteins.