Frozen Views of Met18 Protein Particles

Frozen Views of Met18 Protein Particles

Sheena Vasquez, Melissa D. Marquez, Edward J. Brignole, Amanda Vo, Sunnie Kong, Chris Park, Deborah L. Perlstein, and Catherine L. Drennan

MIT Department of Biology, MIT Department of Chemistry

This image represents 2-dimensional classes of Met18 protein particles. As in, these are averaged images of how Met18 looks when frozen! Each panel represents a different orientation of the protein complex, showing how the complex looks, which can help us understand its function better.

I took these images to understand the structure of Met18 on its own to better understand its function and regulation in the Cytosolic Iron-sulfur cluster Assembly (CIA) pathway. Along with proteins Cia1 and Cia2, Met18 forms the CIA targeting complex (CTC), which transfers a mature iron-sulfur cluster to cytosolic and nuclear client proteins.

a five by six grid ofM protein clusters in blue

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