Hepatocytes and Stromal Cells Pack Together to Form Liver Spheroids 3
Hepatocytes and Stromal Cells Pack Together to Form Liver Spheroids 3
Tiffany Vo
Koch Institute at MIT, Institute of Medical Engineering and Science
This image shows mini engineered livers comprising hepatocytes (liver cells) and supporting stromal cells within a macroporous 3D matrix. One bottleneck in the development of antimalarial drugs and vaccines is the lack of cost-effective and reproduceable human-based disease models for screening. This image of liver spheroids is part of a project that proposes to develop engineered liver tissues that support long-term hepatocyte survival and function to study microenvironmental factors for Plasmodium parasite traversal into the human liver and enable robust malaria infection.