Spatial Expressions: Snapshot of a Growing Tumor

Spatial Expressions: Snapshot of a Growing Tumor

Collections: Image Award Winners, Cancer Discovery Science

2018 Award Winner

Leah Caplan, Jatin Roper, Inbal Avraham-Davidi, Sebastian Santos, Ömer Yilmaz, Aviv Regev

Koch Institute at MIT, Broad Institute, MIT Department of Biology

Combining computer vision with single-cell genome sequencing allows researchers to better understand how cells function and interact within the context of their surrounding environment.

In this image, colon cancer cells (green) from a model developed by the Yilmaz Lab have been sequenced and fluorescently marked by the Regev Lab. Yellow tags identify stem-like qualities while red show active proliferation. Together, they present a snapshot of a tumor’s dynamic properties. The team uses this information to determine which biological factors contribute to tumor growth and cancer progression.

This image was taken on a Nikon TI-E with a W1 spinning disk confocal.


Leah Caplan shares the story behind her award-winning image. You can also watch her presentation from the exhibit opening on March 8, 2018 here.

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