Niche Cells: Stromal Cells Support Intestinal Regeneration

Niche Cells: Stromal Cells Support Intestinal Regeneration

Norihiro Goto, Saori Goto, Omer Yilmaz

Koch Institute at MIT, MIT Department of Biology

Regeneration of intestinal epithelial cells requires their surrounding niche cells in the stroma. This image visualizes two important stromal niche cells that produce R-spondin3 (RSPO3). These cells are lymphatic endothelial cells and RSPO3+GREM1+ fibroblasts. These cells expand and produce more RSPO3 to support post-injury regeneration of the intestine.

a red line of cells with blue flame-like cell clusters extending upward, mixed with red and yellow cells at key junctures

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