Niche Cells: Stromal Cells Support Intestinal Regeneration
Niche Cells: Stromal Cells Support Intestinal Regeneration
Norihiro Goto, Saori Goto, Omer Yilmaz
Koch Institute at MIT, MIT Department of Biology
Regeneration of intestinal epithelial cells requires their surrounding niche cells in the stroma. This image visualizes two important stromal niche cells that produce R-spondin3 (RSPO3). These cells are lymphatic endothelial cells and RSPO3+GREM1+ fibroblasts. These cells expand and produce more RSPO3 to support post-injury regeneration of the intestine.