Poly(ADP-ribose) at Mitotic Spindle Poles

Poly(ADP-ribose) at Mitotic Spindle Poles

Submitted by Sejal Vyas of the Chang Laboratory at the Koch Institute

MIT Department of Biology, Koch Institute at MIT

Sejal Vyas
Chang Laboratory, Koch Institute for Integrative Cancer Research at MIT
Spinning-Disk Confocal Micrograph

"The goal of our research is to understand the functions of the polymeric protein modification poly(ADP-ribose) -- or pADPr -- on various aspects of cell biology such as cell division and stress responses.  This image shows enrichment of pADPr at spindle poles using a novel reagent.  pADPr is required for mitotic spindle formation."

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